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Clinical Trials Centre

The Clinical Trials Centre at Wesley Research Institute has been managing trials since 1994. Clinical trials are a type of research involving human volunteers dedicated to offering new and emerging treatment options to patients with various illnesses and diseases.

About the Clinical Trials Centre

The purpose of a clinical trial is to evaluate new approaches in treating medical conditions or diseases under controlled conditions. This involves determining how well people respond to new treatments, what side effects there are, how well they are tolerated or whether the new intervention is better than those that are already available.

The conduct of high-quality clinical trials is not only essential in the development of new medicines and medical devices, but they are also necessary to find new uses for existing medicines.

The Clinical Trials Centre enables patient participation in national and international phase I-IV clinical trials with a focus on evaluating new therapies, drugs, and diagnostic tools to drive discoveries into standard clinical practice. 

Engaged across four hospitals – The Wesley Hospital, St Andrew’s War Memorial Hospital, Buderim Private Hospital and St Stephen’s (Hervey Bay) – clinicians and patients located in both metropolitan and regional areas can participate.

Our patients are at the heart of all we do and that’s why Wesley Research Institute focuses on providing participants, researchers, and sponsors with a first-class, professional experience.  Our dedicated staff strive for a reputation of integrity and quality, delivering a warm, caring and inviting environment for all participants.

What clinical trials mean to participants

Clinical trials at Wesley Research Institute

Coeliac Disease Clinical Trials

Open for patient recruitment
Dr James Daveson and his team are developing a world leading multi-disciplinary research program for Coeliac Disease and Immune Health. However we can’t do this research without the coeliac community participating and volunteering to take part in clinical trials.
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CONVERT II

Open for patient recruitment
This trial will evaluate lung function changes, hyperinflation (trapped air causing the lungs to become too large), quality of life, and adverse events after the closure of the air channels with the AeriSeal System, followed by the implantation of the Zephyr Valve to achieve bronchoscopic lung volume reduction.  
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APEX

Open for patient recruitment
The study will help us to understand if TX000045 improves blood flow from the lungs back to the heart, improves filling of participants’ hearts with blood and improves participants’ ability to exercise for patients with Pulmonary Hypertension.
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Vertex

Open for patient recruitment
The purpose of this study is to evaluate the safety and tolerability of an investigation study drug compared to a placebo in adults with Myotonic Dystrophy (DM1).
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INSIGNIA

Open for patient recruitment
This trial is testing a new investigational medication in adults with high blood pressure in the lungs (pulmonary hypertension or PH) related to chronic obstructive pulmonary disease (COPD)
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PROSERA

Open for patient recruitment
The purpose of this research study is to determine whether seralutanib is safe and effective when given to people with PAH who are already taking other PAH medications.  
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KAN101

Closed for patient recruitment
This study will investigate the safety and tolerability of multiple intravenous (IV) doses of KAN-101 in patients with well-controlled Coeliac Disease. It is expected to act by reprogramming immune cells to become tolerant towards gluten.
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Chugai

Closed for patient recruitment
The research project is to evaluate the safety, effectiveness, immune response and blood levels of a single subcutaneous (SC) dose of DONQ52, an investigational product, versus a placebo for use in the treatment of Coeliac Disease.
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Encompass Study

Closed for patient recruitment
A Prospective, Single-arm, Multicenter Feasibility Trial to Evaluate the Safety and Performance of the F2 Filter and Delivery System Used for Embolic Protection during Transcatheter Aortic Valve Replacement
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Skin Cancer

Open for patient recruitment
This project aims to find new biomarkers for immunotherapy in patients with melanoma.
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Testing treatments to improve symptoms of Myositis

Open for patient recruitment
Myositis is a disorder in which the immune system attacks the muscles. It is hoped that this new treatment may help improve the symptoms of this disease.
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A practitioner holding a persons leg and pressing their knee

Tranexamic Acid (TXA) Dosing in Primary Total Knee Arthroplasty

Open for patient recruitment
The purpose of the study is to evaluate a product called Tranexamic Acid (TXA) and its best use in patients who are undergoing total knee replacement.
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Dr Falk

Closed for patient recruitment
A phase IIb, double-blind, randomised, placebo-controlled trial to evaluate the efficacy and tolerability of ZED1227 in celiac disease subjects experiencing symptoms despite gluten-free diet
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TROPOS

Closed for patient recruitment
The purpose of this study is to determine the safety and effectiveness of a new Pulmonary Artery Hypertension therapy for patients who are already receiving treatment for PAH.
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Topas Therapeutics GmbH Study

Closed for patient recruitment
A double-blind, randomized, placebo-controlled, phase 2a study  to evaluate the safety, tolerability, and pharmacodynamic (PD) effects of two infusions of escalating doses of TPM502 in adults diagnosed with Coeliac Disease (CeD).
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Determining which draining method is best for Pleural effusion

Closed for patient recruitment
This one year research project aims to compare two commonly used methods of draining the effusion to determine which one is best.
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CONVERT

Closed for patient recruitment
Testing techniques to remove airflow between lung compartments for patients with Pulmonary Disease
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A group of patients sitting together in their wheelchairs

Ataxia-Telangiectasia (AT) Study

Closed for patient recruitment
Ataxia-Telangiectasia (A-T) is a rare genetic disorder with an incidence of approximately three in one million births. Patients with A-T often end up in a wheelchair by the age of ten and have a life expectancy of 25 years. Approximately 40 children in Australia currently have A-T.
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Boy at dentist

Dental Enamel Defects Study

Closed for patient recruitment
Evaluating the prevalence of Coeliac Disease in children with Developmental Defects of Enamel.
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A person mixing baking ingredients in a bowl

Gluten Threshold Study

Closed for patient recruitment
This study will compare small doses of gluten; Each participant is allocated either a dose of gluten or a placebo (which contains no gluten at all) through a process known as randomisation. The dose of gluten/placebo will be administered in a “gluten challenge”, which means that participants will ingest the gluten/placebo and then be observed for side effects.
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WHIM Study

Closed for patient recruitment
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Mavorixafor in Patients with WHIM Syndrome with Open-Label Extension (4WHIM)
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TEVA Study

Closed for patient recruitment
A single-dose phase 1b, randomized, double-blind, placebo-controlled study to characterise the safety and tolerability of TEV-53408 administered subcutaneously in adults with Coeliac Disease 
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MT7117 Study

Closed for patient recruitment
This study is testing a potential new treatment for EPP or XLP that increases melanin in the skin, which protects you from sunlight.
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Contact Us

For more information or if you would like to discuss a new Clinical Trial please contact our team:

Email: clinicaltrials@wesleyresearch.org.au

Phone:  07 3721 1500

Facilities

Wesley Research Institute is swipe card access only and is located on the 8th Floor of the East Wing of The Wesley Hospital.

It offers the following facilities for clinical trials:

  • Four clinical consultation rooms
  • Pathology Laboratory (including 2x vaccine refrigerators with back to base alarms and 24/7 temperature monitoring)
  • Dedicated drug safe
  • Two Patient Observation Lounges
  • Treatment Room
  • 3 x -80˚C freezers
  • -20˚C freezer
  • Refrigerated centrifuge
  • 3 x ambient centrifuges
  • Secure document storage
  • Ample monitoring space
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