An estimated 1 in 70 Australians have coeliac disease, an autoimmune condition triggered by gluten proteins found in wheat, rye and barley, which causes the immune system to attack the small intestine. However, it is estimated that more than 80 per cent of all Australian coeliac sufferers remain undiagnosed.

Patients with coeliac disease can experience a wide range of symptoms. Signs include abdominal pain, bloating, diarrhea, constipation, fatigue and weight loss, although many are now diagnosed on the basis of other symptoms such as iron deficiency, short stature, tooth enamel defects and migraines.

If left untreated, coeliac disease is associated with a three-fold increase in the risk of autoimmune diseases and osteoporosis, as well as a decreased quality of life, and an increase in mortality. The disease can lead to increased risks of nutrient deficiencies, malignancy and unnecessary healthcare costs.

Led by Dr James Daveson, this research program is a multidisciplinary collaboration involving patients, medical practitioners, hospitals and researchers. The research aims to deepen our understanding of autoimmune disease onset and progression, develop new diagnostic tools and create more effective interventions to help manage this debilitating disease.